Abstract
In this paper, we demonstrated mimicking of natural skeletal muscle tissue by integration of gel fiber containing muscle cells fabricated using microfluidic device. Gel fiber was mainly composed of sodium alginate gel and fibrin gel, its fibrin gel plays a key role as cell scaffold for cell growth and elongation. Gel fiber containing muscle cells was rolled up and transferred between silicon tube pillars to culture while apply tensile strength. After that, sodium alginate gel which inhibits cell growth and elongation was dissolved by immersing into 1μg/mL alginate lyase solution. As a consequence, shrinkage of integrated gel fiber containing muscle cells was confirmed at about twelve hours from culture, and anisotropic cell growth and elongation along integrated gel fiber direction was observed at the same time. This result represents mimicking of a part of natural skeletal muscle tissue and possibility of muscle contraction by culture in differentiation medium.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
