男性インポテンスに関する研究

Abstract

As a diagnostic technique for differentiating between organic and functional impotence, we have developed the “radioisotope penography” to identify the features of intrapenial blood flow in patients. As an isotope for our penography, we previously used simply 131I-human serum albumin, 113mIn-micro-colloid, or 99mTcO-4-. But recently a unique method using 99mTc-labeled autologous red blood cells has been developed and apparently is preferable to any of the foregoing isotopes in quantitating intrapenial blood. This is a report on our radioisotope penographies using 99mTc-labeled autologous red blood cells and some of the clinical results obtained.In 25 impotent patients, radioisotope penography was performed using 99mTc-red blood cells (labeling the patient's own red blood cells with 99mTc) for quantitative analysis of intrapenial blood volume. A visual sexual stimulation (V. S. S.) was shown the patient after injection of 99mTc-red blood cells. Patients showing a complete erection had an increase in pooled blood 4.2-11.2 times greater than before the V. S. S. (mean increase, 8.0). In cases with incomplete erections after the V. S. S., intrapenial blood volumes were 3.3-7.0 times greater than before the V. S. S. (mean increase, 4.9). In cases showing a gentle rise in their penogram curves without evidence of an erection, intrapenial blood volumes after the V. S. S. were 2.0-3.3 times those before the V. S. S. (mean increase, 2.9). By contrast, in those cases showing no response to the V. S. S. and no rise in their penogram curves, post-V. S. S. increase in intrapenial pool of blood was very slight, only 1.4-1.7 times the original volume.