Abstract
The antigenic structures of Corynebacterium including C. diphtheriae and others were studied by agglutination reaction and it was confirmed that the strains so far tested contained heat-labile and Oinagglutinable antigen and heatstable antigen. The heat-labile antigen was rather type-specific and strainspecific and heat-stable antigen was cross-reacting to almost all of the tested strains including C. belfanti, C. hofmannii, C. xerosis, and C. ulcerans.In this connection the experimental allergic reaction of guinea pig was investigated and it was confirmed that heat-stable antigen other than toxoid could be responsible for the allergic reaction to the crude toxoid in the market, but it did not sensitize the guinea pig against the purified diphtheria toxoid in the purity of 3300 Lf per mg. P. N.And it was confirmed that the guinea pig could be sensitized against the diphtheria toxoid in the purity of 3300 Lf per mg. P. N.
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