Abstract
Urokinase (UK) immobilized material is known to have excellent antithrombogenicity. This antithrombogenicity has been ascribed to the fibrinolytic activity of plasmin activated by UK.We found that platelet adhesion was not recognized on the surface of UK immobilized polyurethane catheter indwelled in vein. To investigate the interaction between platelet adhesion and fibrinolytic activity, inactivated immobilized UK was prepared by chemical modification with (p-amidinophenyl) methanesulfonyl fluoride hydrochloride. Polyurethane, UK immobilized polyurethane and inactivated UK immobilized polyurethane were incubated with human blood in Chandler loop and their surface were observed by scanning electronmicroscopy. Platelet adhesion on the surface of the material was recognized for polyurethane but not observed for UK immobilized polyurethane and inactivated UK immobilized polyurethane.We concluded that the antithrombogenicity of UK immobilized material depends not only on fibrinolytic activity but also inhibition of platelet adhesion which is not mediated with plasminogen activation by urokinase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
