Abstract
In this objective evaluation of the efficacy of prophylactic treatment for Japanese cedar pollinosis during natural allergen exposure, topical ketotifen (0.3-0.4mg/day) was administered during the spring of 1992. Ten patients received prophylactic treatment, and others were treated after the onset of symptoms. Subjective symptom scores, blood eosinophil counts and serum MBP values were examined and compared.The total subjective symptom scores, blood eosinophil counts and serum MBP values in the prophylactic treatment group were significantly lower than in the group treated after the onset of symptoms. Thus, the effect of prophylactic treatment can be evaluated objectively.
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