下部尿路の尿流動態研究

Abstract

A small and portable urethral pressure profilometer, which has a dual mechanism of catheter withdrawal and water infusion, has been constructed based upon the urethral pressure profilometry performed on female dogs. Over 100 clinical materials have been examined by this machine without any complications.1. A nelaton catheter of 10F for adults or 8F for infants, which had 4 small holes 3cm from the distal end, was transversed from the bladder to the external urethral orifice with a withdrawal speed of 30mm/min and a water infusion rate of 2.5ml/min.2. Clinical presentation of characteristic urethral pressure profiles was made in accord with their symptoms; 6 healthy adult males and females, 2 cases of untoward effect of anesthesia, 4 cases of prostatic disease, 6 cases of urethral disease, and 6 cases of neurogenic bladder dysfunction. Cystourethrogram, uroflowmetrogram and cystometrogram were also illustrated in some cases.3. Normal values of urethral pressure profile were defined. Maximum urethral pressure averaged 78.3mmHg in adult male and 69.8 mmHg in adult females. Total profile length was 13 to 16cm in male and 25 to 46mm in female. The distance from the inner urethral orifice to the point of maximum urethral pressure was 10 to 25mm in male.4. Assessment of urethral function was made in various diseases which interfered with urethral pressure profile qualitatively and quantitatively Urethral pressure profilometry is a valuable clinical tool to evaluate the physical properties of urethral wall and the functional disorder present in the urethral sphincter.