Abstract
Hydroxyapatite (HAP) is considered one of the best bioactive ceramics because of its high osteoconductivity. Although it has several characteristics of an ideal bone substitute, it does not possess osteoinductive activity.On the other hand, bone morphogenetic protein (BMP), which can induce the differentiation of mesenchymal cells into cartilage and bone, can be extracted from bone matrix.We used true bone ceramics (TBC) particles, instead of artificial HAP, together with atelocollagen (AC) and BMP as a bone substitute.The bone-inducing and bone-regenerating potency of TBC-AC-BMP composite was evaluated to determine its value as a bone-inductive biomaterial.TBC-AC composite and TBC-AC-BMP composite were implanted into rat skull defects. The animals were sacrificed every 2 weeks after implantation and examined by radiographical and histological methods. The calcium content of the newly formed bone in the implant sites was determined spectrophotometrically using o-cresolphthalein complexone (OCPC) method.In this animal experiment, TBC-AC-BMP composite produced new bone more rapidly than TBC-AC composite, and it produced larger quantities of new bone formation from an early stage.From the results of this study, TBC-AC-BMP composite has excellent bone-inducing ability and has the possibility to become an ideal bone substitute.
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