Abstract
The effects of plasma lipoproteins on platelet aggregation were examined after incubation of platelet rich plasma (PRP) and different concentrations of plasma lipoproteins for 30-60min at room temperature.Platelet aggregation was measured after addition of adenosine diphosphate (ADP) by Aggregation Meter of SIENCO company. Final concentration of ADP was 2μM.PRP were prepared from normal subjects and patients with cerebral thrombosis and plasma lipoproteins were concentrated and divided into three fraction of very low density (VLDL d<1.006), low density (LDL 1.006<d<1.63) and high density (HDL 1.063<d<1.21) lipoproteins by the ultracentrifugation of Havel's method.No significant changes of platelet aggregation were observed in both groups by the incubation of PRP with VLDL, LDL and HDL.We conclude that plasma lipoproteins have no effects on platelet aggregation in short time incubation.
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