Abstract
Free radical cyclization is rapidly becoming an important method for the synthesis of cyclic compounds. This review summarizes our recent studies on the synthesis of nitrogen-containing heterocycles by means of cyclization of N-alkenic carbamoylmethyl radicals which are generated from the corresponding α-haloamides by treatment with tributyltin hydride in the presence of azobis (isobutyronitrile) (AIBN) Ruthenium-catalyzed chlorine atom transfer cyclizations of α-chloro-α-thioacetamides have also been examined. These reactions are classified into several types of ring closures including relatively difficult 4-exo-trig and 5-endo-trig cyclizations which provide β- and γ-lactams, respectively. Applications of the method to the synthesis of natural products are also presented.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
