光触媒を利用した安全キャビネット内残留抗癌剤分解の検討

Abstract

There are hopes that the amounts of residual anticancer agents contaminating the biological safety cabinet (BSC) andpreparation room can be reduced.Degradation solutions such as sodium hydroxide solution have been recommended forwiping away residual anticancer agents in the BSC.However,the effectiveness of such solutions in degrading anticanceragents has not been sufficient.In this study,we attempted to reduce the contamination due to anticancer agents in the BSC using a photocatalyst consistingof titanium dioxide (TiOcitation=2)that produces free-radicals when irradiated with near-ultraviolet light (near-UV).We dropped several concentrations of cyclophosphamide on a stainless steel plate coated with TiO2 in the BSC and irradiatedwith near-UV for 12 hours.As another method,we sprayed on the photocatalyst.Solutions containing TiO2 (0.1%w/v and 0.3% w/v) were sprayed on to an uncoated stainless plate,cyclophosphamide was dropped on to it and the platewas irradiated with near-UV in the BSC.Following irradiation,the plates were wiped,the wiped off cyclophosphamide wasextracted and its amount measured using high-performance liquid chromatography.We found that 1 mg,0.1 mg and 0.05mg of cyclophosphamide dropped on to the photocatalyst coated plate were degraded by 44%,89%,and>93% (belowquantification limit) respectively.At 0.1% w/v the photocatalyst spray degraded 4 mg and 1 mg of cyclophosphamide by63% and 60%,respectively,while at 0.3% w/v,the photocatalyst spray degraded 4 mg and 1 mg of cyclophosphamide by39% and 83%,respectively.In conclusion,the photocatalyst was useful in the degradation of residual anticancer agents in the BSC.