喉頭ポリープの免疫組織学的観察

Abstract

Seven laryngeal polyps surgically removed from 7 adult patients were examined immunohistochemically to identify presence of the following substances : keratin, transferrin, lactoferrin, fibrinogen, vimentin, factor VIII, EMA (Epithelial Membrane Antigen) and S-100 protein.There was a considerable amount of keratin and EMA in the atrophied stratified squamous epithelial cells.Vimentin was present in a large size of mesenchymal cells, which were distributed in the subepithelial tissues of fibrous polyps.A great amount of transferrin, fibrinogen and factor VIII was noted in the subepithelial tissue of the polyps, primarily of the edematous and/or hematomatous types. Since these substances are serum protein, this suggests that they were delived from serum due to increased vascular permeability.Immunostaining for S-100 protein revealed no nerve fibers in the laryngeal polyps.It is concluded from the present observation that laryngeal polyps are formed by a subepithelial retention of the blood constituents due to local vascular disturbances.