Abstract
We examined the drug interaction between zonisamide (ZNS) and carbamazepine (CBZ), valproic acid (VPA) or phenobarbital (PB) in 27 epileptic patients by monitoring the ratio of serum concentration at the steady state to the ZNS dose administered (C/D ratio). The C/D ratio ZNS therapy combined with CBZ was significantly decreased over that of ZNS monotherapy (p<0.01) whereas VPA or PB did not change the ZNS C/D ratio. Furthermore, the ZNS C/D ratio decreased with increasing the CBZ dose.Accordingly, careful therapeutic drug monitoring should be done when administering ZNS concomitantly with CBZ.
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