Abstract
Polyethylene glycol (PEG) ointment for rectal application containing thiamylal sodium was prepared for premedication of anesthesia and first-aid of pediatric spasmodic disease. The rate of release of thiamylal sodium ointment base was determined by JP X dissolution test and cylindrical method, and showed the increase in parallel with the mixing ratio of PEG 400. Thiamylal sodium in PEG ointment base stored at 4±1°C was stable for 3 months.As a results of the test on spreadability, penetration, rate of release from base and stability, it was suggested that the suitable mixing ratio of PEG 4000 and PEG 400 was 1: 5. Plasma peak level of thiamylal sodium following rectal administration of ointment appeared more rapidly than that of suppository. It has become feasible to have more rapid anesthetic action of ointment than that of suppository.
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