Abstract
Directly injecting folic acid or vitamine B12 into the femur bone marrow of experimental anemic rabbits, and then injecting P32 solution in the auricular vein, the activity of P32 was examined on the bone marrow dividing into DNA, RNA and phosphoprotein.1) In the case that the hematopoietic function of bone marrow was normal (normal rabbit) or somewhat increased (rabbit with venesection) or even the case that the function declined moderatly (rabbit injected benzol with small dose), the nucleic acid phosphorus metabolism of bone marrow proves a rise by the direct injection both folic acid and vitamine B12.It is thought, therefore, that both of them can stimulate the hematopoietic function of bone marrow directly. Vitamin B12 is more powerful compared with the folic acid.2) In case that the hematopoietic function of bone marrow was seriously damaged (case of rabbit administered by large doze of benzol or nitrogen mustard), neither folic acid nor vitamine B12 could stimulate the hematopoietic function of bone marrow.
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