Abstract
(1) Observations were made on 15 specimens of biopsies obtained from 5 cases of tuberculoid leprosy, each taken from the cutaneous sites of Mitsuda reaction. The following results were obtained.(2) Within the first three days after injection, an inflammation of the nonspecific, acute exsudative type was observed. Tuberculoid granulation was observed 8-14 days after injection.(3) It was observed that the injected bacilli were destroyed in the tissue earlier than in the neural cases.(4) The allergic nature of the early reaction, Bungler and Fernandez has stated, could not be found from histopathological standpoint.(5) The histopathological picture of Mitsuda reaction is the tuberculoid granulom caused by the destruction product of injected lepra bacilli.(6) There are no essential difference between neural and tuberculoid leprosy from the view of histological manifestation of Mitsuda reaction.
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