Abstract
The effects of ultrasound on the skin bioconversion of estradiol esters were investigated in the hairless mouse skin pretreated by ultrasound in vitro. The time-course of the drugs was well described by the first order reaction kinetics with or without ultrasound pretreatment. The ultrasound markedly reduced the rate constants of skin metabolism of β-estradiol diacetate (ED) as well as β-estradiol mono-acetate (EA).
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