Abstract
The effects of garlic components extracted with organic solvents on the carbohydrate and fat metabolism of rats were investigated. Rats fed on a diet prepared according to the AIN-76 formula were given either the garlic extract or saline for 5 weeks via an intra-peritoneal injection. The liver weight of the garlic group decreased, but their thyroid glands increased significantly in wet weight compared to the control group. The weight of the carcass was suppressed in the garlic group, and crude fat content in the carcass significantly decreased. The glycogen synthetase activity in the liver cytosol of the garlic-supplemented rats was also significantly decreased, as was the plasma insulin concentration, while the plasma glucagon concentration of the garlic group was elevated. It is suggested from these data that dietary supplementation with the garlic extract might have promoted the catabolism of glucose and/or fatty acid (combustion) in the rats.
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