Abstract
Recent studies of hormones in the inner ear are described. The possibility that hormones act on the cochlea through the adenylate cyclase-cyclic AMP system and through the regulation of blood flow in the cochlea is dicussed, though no direct evidence supporting this hypothesis yet exists. The action of hormones on the vestibule is still unknown. In the endolymphatic sac, direct evidence supporting the action of catecholamines on the endolymphatic sac has recently been obtained. Our recent study revealed that catecholamines change the oxygen-dependent positive DC potential in the endolymphatic sac of the guinea pig in a reversible manner. The involvement of aldosterone in regulating the functions of the endolymphatic sac has also been suggested. It is assumed that the endolymphatic sac may be an important tissue for hormonal regulation in the inner ear.
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