Abstract

Evoked otoacoustic emissions (EOAEs) were recorded from patients with Meniere's disease and the “main frequency” of the emissions, which shows the maximal peak in the frequency spectrum, was examined as a variable. The results were as follows: 1) EOAEs were detected even in ears with moderate or severe hearing loss of more than 50 dBHL. 2) The main frequencies in ears with Meniere's disease ranged mainly from 0.8 kHz to 1.1 kHz and existed at lower frequencies than that in those with normal hearing which ranged mainly from 1.0 kHz to 1.6 kHz. 3) The main frequency changed from lower to higher after administration of osmotic diuretics such as isosorbide or glycerol. 4) On serial observations along the time course, the changes in the main frequency corresponded to those of the clinical state of Meniere's disease. From these observations, it was speculated that in ears with Meniere's disease, lower frequency dominant emissions might be elicited by modification of the basilar membrane in endolymphatic hydrops and that the main frequency changed from lower to higher with reduction of endolymphatic hydrops induced by osmotic diuretics. It was considered that the EOAE testing might be useful in diagnosing endolymphatic hydrops in Meniere's disease.

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