Abstract
Dietary supplementation of omega-3 polyunsaturated fatty acid（PUFA）includingeicosapentaenoic acid（EPA）and docosahexaenoic acid（DHA）is widely held to be beneficial in human health. Also, elevation in omega-3 PUFA levels in omega-3desaturase（ fat-1）transgenic mice that endogenously biosynthesize omega-3 PUFA from omega-6 PUFA exhibits resistance to inflammatory disease models. To elucidate the molecular mechanisms underlying the beneficial effects of omega-3 PUFAs, we developed a comprehensive LC-MS/MS-based lipidomics method that can detect and quantify more than 500 of PUFA metabolites simultaneously. Using this lipidomics system, and genetically modified animals or nutritional control to manipulate fatty acid balance in the body, we try to understand how different balance of omega-3/omega-6 fatty acids and their unique metabolites function in vivo that could explain the biological significance of omega-3 PUFAs in controlling inflammation and related diseases.
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