Abstract
Spherically microagglomerated crystals of waxy drug (tocopherol nicotinate) for direct tableting were successfully prepared by a spherical crystallization technique. The micromeritic properties of the original tocopherol nicotinate crystals, such as flowability, packability, and mixing characteristics with excipients were drastically improved for tableting. The surface-modified agglomerated crystals with deposition of colloidal silica reduced sticking (caking) properties under loading and exudation of drug from agglomerated crystals under compression. The agglomerated crystals provided acceptable tablets with easily disintegrating and releasing functions by compressing with a suitable additives.
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