Abstract
The level of cefuzonam (CZON) in otorrhea discharge was measured to evaluate the clinical effectiveness of this drug in the treatment of middle ear infection. The concentration of CZON ranged from 1, μg/g to 2μg/g for 4 hours after 1g single i. v. injection (SIV), 2μg /g to 6μg/g for 3 hours after 2g SIV, 1μg/g to 2μg/g for 2 hours after 1g i. v. drip infusion (IVD) over 30 minutes, and 2μg/g to 5μg/g for 2 hours after 2g IVD over 30 minutes. In the cases of chronic otitis media including cholesteatoma, the most commonly isolated bacteria were Staphylococcus aureus (25.6%) and Pseudomonas aeruginosa (25.6%), followed by Staphylococcus epidermidis (8.5%). In the literature, the MICgo of CZON is reported to be ≤ 1.56μg/ml for Staphylococcus aureusexcept MRSA and 6.25μg/ml for Staphylococcus epidermidis. CZON is effective against all these bacteria except Pseudomonas aeruginoa.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
