Abstract
Optimum conditions for the determination of chloroquine in biological materials using gas chromatograph equipped with 10 mCi 63Ni electron capture detector has been investigated. A U-shaped glass column (3 mm × 2 m) was packed with 3% silicone OV-17 coated Gaschrom Q (mesh 100/120). Nitrogen was used as a carrier gas. The column oven was regulated to 260°, and the detector oven and the injection port were at 280°. Chloroquine was extracted with hexane from the standard solution or rabbit urine saturated with potassium carbonate. The calibration curve was drawn with the use of O-ethyl O-(p-nitrophenyl) phenylphosphonothioate as an internal standard. A few nanogram chloroquine can be determined by this procedure.
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