Abstract
The variation in serum disopyramide concentration at early morning (6: 00) in inpatients administered 300mg per day of sustained-release disopyramide tablet (Rthmodan R, preparation A) or the same dose of non sustained-release disopyramide capsule (Rthmodan, preparation B) was studied. Twenty-one inpatients, whose mean age was 68.4 ±10.2 (SD) yr and mean body weight was 52.0±7.6kg, received preparation A (q 12 hr at 7: 00 & 19: 00). Nineteen inpatients, whose mean age was 68.3±12.9 yr and body weight was 54.0±11.3kg, received preparation B (tid at 7: 00, 12: 00 & 19: 00). No differences were observed in the mean ratio of serum disopyramide concentration at 6: 00 to dose between inpatients receiving preparations A and B, although a signficant difference was observed in its variation. When the intra-individual variability in inpatients monitored more than three times was compared, the CV was 4.93±1.74%(SD) in inpatients receiving preparation A versus 21.8±7.8% in inpatients received preparation B. Therefore, this suggests that the variation in serum disopyramide concentration in inpatients receiving preparation A was significantly decreased over that of preparation B.
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