Abstract
Using male rats pretreated with phenobarbital (PB), fasted, and then exposed to 0.7% halothane at 10% or 100% oxygen, the content and activity of hepatic microsomal enzymes were measured. The content of cytochrome b5 and the activity of NADPH-cytochrome P-450 reductase were increased by PB-pretreatment, but not changed by exposure to halothane at 10% or 100% oxygen. Although the content of cytochrome P-450 (P-450) and the activity of aminopyrine demethylation were increased by PB-pretreatment and decreased by exposure to halothane at 10% oxygen, aniline hydroxylation activity was decreased by PB-pretreatment and not changed by exposure to halothane. These results suggested that the subtypes of P-450 which were increased by PB-pretreatment were decreased by exposure to halothane at 10% oxygen. A close relationship may exist between the decreases in content of P-450 and the development of hepatic injury following halothane anesthesia in rat.
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Schedule a callMore From: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
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