Abstract
Effectiveness of a hepatic targeting system utilizing carbohydrate recognition mechanism was evaluated. Three types of bovine serum albumin (BSA)derivatives with 1-thiogalactoside(Gal-BSA), 1-thioglucoside(Glc-BSA), and 1-thiomannoside (Man-BSA) were synthesized by the amidation method and their disposition characteristics in mice were studied. Gal-BSA and Glc-BSA were rapidly taken up by the liver parenchymal cells, while Man-BSA was accumulated in the non-parenchymal cells due to receptor-mediated endocytosis. Similar results were observed in glycosylated superoxide dismutase and carboxymethyldextran, suggesting wide applicability of this methodology.
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