Abstract
Fungicidal activities of six kinds of disinfectants, such as chlorhexidine digluconate (CHX), benzalkonium chloride (BAC), alkylpolyaminoethylglycine (APE), formalin (FON), cresol soap (CRS) and povidone iodine (PVI) were investigated against 8 clinical isolated fungi, which included 1 Aspergillus niger, 1 Aspergillus terreus, 2 Candida albicans, 2 Candida tropicalis, 1 Candida parapsilosis, 1 Cryptococcus neoformans, 1 Trichophyton rubrum and 1 Rhodotorula glutinis strains. Concentrations of fungal suspensions were adjusted to approximately 107CFU/ ml for A.niger, A.terreus and T.rubrum and 108-9CFU/ml for C.albicans (A), (B), C.tropicalis (A), (B), C.parapsilosis, C.neoformans and R.glutinis strains, respectivelyThe fungal suspensions with the various concentration of disinfectant were incubated at 25°C, for 15, 30, 60min.and 24 hrs, respectively.An aliquot (0.1ml) was inoculated onto the Sabouraud-glucose agar plates, and the growth was observed after 7 days of incubation at 25°C. Among the 5 strains tested, A.niger was the most resistant one to all disinfectants examined, and 0.4% concentration of CHX, APE or CRS was found to be effective against A. niger strain for lhr.It was considered that BAC, FON or PVI was more effective against the fungi tested than CHX, APE or CRS in short time.
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