Abstract
We evaluated whether or not eosinophil infiltration induced by an antigen (ovalbumin) inhalation caused the damage of the bronchial epithelium. The inhibitory effects of the anti-allergic drug, Ibudilast (Ibd), on eosinophil infiltration, eosinophil activation and epithelial tissue damage were also examined. Fourteen days pretreatment of Ibd inhibited eosinophil infiltration in the epithelial and subepithelial tissue 6, 24 hours after an antigen inhalation. A significant correlation was noted between change of the electron densities of the eosinophil specific granules and the damage of tracheal epithelium 6 hours after an antigen inhalation. Changes of the electron densities of the eosinophil specific granules suggest the activation of the cells.The observation in this study shows that infiltrated eosinophils were activated and contributed to the damage of the bronchial epithelium by releasing toxic granules proteins and may explain the mechanism that Ibd exerts bronchial hypersensitivity.
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