家兎の実験的動脈硬化症に及ぼすクロレラの効果

Abstract

The effects of dried Chlorella powder on lipid metabolism and pathological changes of aortae were investigated in cholesterol-fed rabbits, using clofibrate for comparison. Japanese white male rabbits were fed on a high cholesterol diet for 20 weeks in the following manner: 1) High cholesterol diet (0.5% cholesterol in normal stock diet), 2) High cholesterol diet plus 1% Chlorella, 3) High cholesterol diet plus 5% Chlorella, 4) High cholesterol diet plus 0.5% clofibrate.Administration of Chlorella inhibited the increase of serum total cholesterol and phospholipid levels caused by cholesterol feeding. The percentage of atherosclerotic intimal involvement was significantly lower in Chlorella-fed groups than cholesterol-fed group. Clofibrate did not affect the levels of serum lipids, but it reduced the aortic intimal involvement.