Abstract
Hydrophilic nylon microcapsules containing concanavalin A and succinyl-amidophenyl-glucopyranoside insulin (SAPG-insulin), whose average diameter was 70 γm were prepared to achieve a self-regulating insulin delivery system. The microcapsules were enclosed in polymer membranes for in vitro assessment and the release of SAPG-insulin was evaluated under a flow condition of glucose solution. The amount and the rate of SAPG-insulin released from this pouch were dependent upon the external glucose concentration around the pouch. Also, SAPG-insulin was quickly released from a pouch in response to the change of the external glucose concentration. In addition, to optimize this self regulating insulin delivery system, we studied the kinetics of solute permeation through a membrane separating two compartments : donor and receiver under the condition that the receiver compartment was continuously eluted.
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