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Abstract
N-(9-Hydroxy-9H-fluoren-2yl)-acetamide (9-OH-FAA ∗), N-(9-oxo-9H-fluoren-2yl)-acetamide (9-O-FAA), and N-(9H-fluoren-2yl)-glycolamide (FGA) were found in the neutral fraction of microsomal metabolites of N-(9H-fluoren-2yl)-acetamide (FAA). 9-OH-FAA and 9-O-FAA are new metabolites of FAA. The former was identified by R f value, by u.v.- and n.m.r.-spectroscopy, the latter by R f value and u.v.-spectroscopy. 9-OH-FAA was also found in the urine of rats and guinea-pigs injected with FAA. Treatment of rabbits and guinea-pigs with 3-methylcholanthrene diminished microsomal 9-hydroxylation of FAA and stimulated the production of FGA, whereas treatment with phenobarbital did not do so.
Published Version
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