N-3 pufa dietary enrichment modulates mitochondrial dynamics, increases mitophagy and reverses uremia-induced mitochondrial dysfunction in rat skeletal muscle

Abstract

Rationale: Chronic kidney disease (CKD) induces global and profound skeletal muscle mitochondrial alterations, which contribute to muscle mass loss and ultimately negatively affect patient outcome. Among derangements, changes in fission and fusion as well as in mitophagy are known to regulate mitochondrial function. n-3 polyunsaturated fatty acids (PUFA) reportedly improve mitochondrial function in several tissues and disease models, however their potential to modulate muscle mitochondrial dynamics, mitophagy and ultimately function in CKD is currently unknown.