Abstract
This study examines the relationship between erythrocyte phospholipid FA composition and insulin sensitiv?ity in obese patients on a typical Serbian diet. In 30 patients, two insulin sensitivity groups were formed and their FAs analyzed. The shares of 22:5n-3, 22:6n-3, and total n-3 PUFAs, as well as a measure of ?5 desaturase activity (the 20:4n-6/20:3n-6 ratio) were lower in the insulin resistance group compared to the normal glucose tolerance group. The fasting insulin level and HOMA value were inversely related to the percentage of 22:5n-3, 22:6n-3, and total n-3 PUFAs. Our data indicate that the percentage of n-3 PUFAs in erythrocyte phospholipids is linked with insulin sensitivity parameters in obese patients.
Highlights
Obesity is one of the most important risk factors for the development of type 2 diabetes (Colditz et al, 1990)
We have demonstrated that membrane fatty acid composition is related to insulin sensitivity in overweight/obese patients with hyperlipidemia
Since erythrocyte fatty acid composition reflects dietary essential FA intake, this suggests that increased polyunsaturated fatty acid (PUFA) intake, especially uptake of long-chain n-3 PUFAs, could provide a simple mechanism for increased insulin responsiveness in obese patients on a typical Serbian diet low in n-3 PUFAs
Summary
Obesity is one of the most important risk factors for the development of type 2 diabetes (Colditz et al, 1990). Results of some cross-sectional studies that investigated the correlation between erythrocyte membrane fatty acid composition and insulin sensitivity (Agostoni et al, 1994; Clifton and Nestel, 1998; Enriquez et al, 2004; Rodriguez and Christophe, 2005) indicate that this relation may differ, depending on the type of population studied. In obese type 2 diabetics receiving metformin therapy, different relationships were observed: the fasting insulin level correlated positively with alpha-linolenic (18:3n-3) and dihomogamma-linolenic (20:3n-6) acids and negatively with the fraction of palmitic acid (16:0) in erythrocyte phospholipids (Enriquez et al, 2004). Using membrane fatty acid composition as an objective index of dietary fatty acid intake, we obtained results in a cross-sectional study that may aid the planning of nutritional strategies designed to prevent the development of type 2 diabetes in obesity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
