Abstract
One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
Highlights
Actinodaphne pruinosa is a tree of moderate size found in Peninsular Malaysia and Jawa, Indonesia
(+)-N-(2-Hydroxypropyl)lindcarpine (1; see Figure 1) exhibited a molecular formula of C21H26NO5 based on the HRESIMS spectrum which showed a pseudomolecular ion at m/z
There has been no report on the phytochemical study and medicinal value of Actinodaphne pruinosa. This is the first report on the occurrence of N-(2-hydroxypropyl)aporphine type of alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1) which exhibited significant cytotoxicity against P-388 murine leukemia cells
Summary
Actinodaphne pruinosa is a tree of moderate size (about 30-40 feet) found in Peninsular Malaysia and Jawa, Indonesia. Chemistry Department, Faculty of Science and Technology, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia; E-mail: azlan@upsi.edu.my (M.A.N.) Abstract: One new alkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1), together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). Actinodaphne plants of the family Lauraceae have been reported to produce isoquinoline alkaloids (aporphines, oxoaporphines) and lactones [3,4].
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