Abstract
N-[2-(Cyclohexylamino)-2-oxoethyl]-N-(4-octyloxy)phenyl-prop-2-enamide was prepared in good yield by coupling of 4(octyloxy)aniline, Cyclohexyl isocyanide, paraformaldehyde and acrylic acid by multicomponent Ugi reaction, at room temperature. The structure of the newly synthesized tripeptoid derivative was well characterized using elemental analysis, FTIR, NMR and mass spectral data.
Highlights
The field of peptidomimetics has seen an exciting development over the past several years, partly due to the considerable biological importance and putative proteolytic stability of synthetic peptoids over native peptides [1,2,3]
Biswas et al reported a new class of peptoid-based low molecular weight organogelators by the aza-Michael addition reaction between glycinamide and substituted alkyl acrylates [18]
We report the preparation of new tripeptoid with functional acryl and cyclohexyl moiety
Summary
The field of peptidomimetics has seen an exciting development over the past several years, partly due to the considerable biological importance and putative proteolytic stability of synthetic peptoids over native peptides [1,2,3]. Ugi coupling [4,5,6,7,8] of various carboxylic acids, amines, isocyanates and aldehydes to a series of tripeptoids has been found to give excellent yields and these have been reported to exhibit antifungal and antimicrobial activities [9,10,11,12,13]. In addition to such applications, tripeptoids find application as low molecular weight gelators (LMWGs) [14,15]. The structure of the title compound was confirmed by 1 H, 13 C-NMR, FTIR, and mass spectral data
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