N-[(2-Chloro-6-methylquinolin-3-yl)methyl]aniline

Suresh Kumar,Sushma Drabu,Sandhya Bawa

doi:10.3390/m618

Abstract

Quinolinyl amines are important organic compounds which possess a variety of pharmacological activities such as antimalarial, antifungal, hypotensive and antidepressant activity.

Highlights

Quinolinyl amines are important organic compounds which possess a variety of pharmacological activities such as antimalarial, antifungal, hypotensive and antidepressant activity [1,2,3,4]
From the various conditions adopted for the synthesis of secondary amines reported in the literature, synthesis via nucleophilic substitution is still an important method [5]
The solvent was removed under reduced pressure and the residue was dissolved in ether, washed with sodium bicarbonate solution (10%, 25 mL) and twice with water (25 mL), dried over sodium sulphate and concentrated in vacuo to give a residue which was crystallized from methanol

Summary

Introduction

Quinolinyl amines are important organic compounds which possess a variety of pharmacological activities such as antimalarial, antifungal, hypotensive and antidepressant activity [1,2,3,4]. From the various conditions adopted for the synthesis of secondary amines reported in the literature, synthesis via nucleophilic substitution is still an important method [5]. As a part of our research programme on quinoline derivatives [6], we report the synthesis of N-[(2-chloro-6-methylquinolin3-yl)methyl]aniline (Figure 1) by nucleophilic substitution of 2-chloro-3-(chloromethyl)-6methylquinoline with aniline in absolute ethanol in the presence of triethylamine (TEA) as base

Experimental and Section

Findings

Conclusions