Abstract
N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized by reacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Characterization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis.
Highlights
In the past decades, because of their wide variety of pharmacological applications, amides have been considered as important pharmacophores
Characterization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis
13C-NMR spectra were recorded for the compound on an Agilent Mass spectrometer and on a Bruker Avance II (399.65 MHz for 1H-NMR, 100.50 MHz for 13C-NMR) instrument, respectively
Summary
Because of their wide variety of pharmacological applications, amides have been considered as important pharmacophores. Abstract: N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized by reacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Characterization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis. Amides bearing a trifluoromethyl substituent show a broad spectrum of pharmacological properties, including antitumour [1], anti-inflammatory [2], antioxidant [3], analgesic [4] and antiviral activity [5].
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