Abstract
BackgroundFibrosis surrounding cancer cells has been shown to affect cancer cell metastatic behavior. The present study aimed to explore the utility of myxoid stroma as a predictive factor for postoperative relapse in patients with stage II colon cancer.MethodsThe present study retrospectively investigated 169 patients who underwent curative surgical resection of stage II colon cancer. The fibrotic stroma was classified according to Ueno’s criteria, and the patients were divided into the myxoid (MY) group and the non-MY (NMY) group. We also recorded tumor budding (TB) and investigated the combination of MY and TB for postoperative relapse. Postoperative survival was also explored.ResultsThirty-two (18.9%) patients had MY. MY was significantly associated with tumor budding (TB) and postoperative relapse (p < 0.001 and p < 0.001, respectively). The 5-year RFS rates in MY group and NMY group were 52.1 and 94.6% (p < 0.0001), and the 5-year OS rates in MY group and NMY group were 74.6 and 93.3% (p = 0.001). Multivariate analysis showed that both MY and TB were significant risk factors for postoperative relapse (p < 0.001 and p = 0.02, respectively), and that only TB was a significant risk factor for OS (p = 0.043). Furthermore, compared with patients with either one of MY or TB, patients with both MY and TB had postoperative relapse more frequently (11.4% vs. 53.8%).ConclusionsThe present study suggests that MY is a predictive marker for postoperative relapse in patients with stage II colon cancer.
Highlights
Fibrosis surrounding cancer cells has been shown to affect cancer cell metastatic behavior
The actual role of adjuvant chemotherapy (AC) in patients with stage II colon cancer remains unclear despite several clinical trials and meta-analyses [1,2,3,4]
Current molecular and genetic studies have indicated that tumor progression, growth, and spread are determined by the interaction between a cancer and its surrounding stromal cells [13, 14]
Summary
Fibrosis surrounding cancer cells has been shown to affect cancer cell metastatic behavior. The present study aimed to explore the utility of myxoid stroma as a predictive factor for postoperative relapse in patients with stage II colon cancer. International guidelines recommend that patients with stage II colon cancer should be Current molecular and genetic studies have indicated that tumor progression, growth, and spread are determined by the interaction between a cancer and its surrounding stromal cells [13, 14]. The tumor stroma contains many different cells, including lymphocytes, macrophages, leukocytes, Rouget cells, vascular endothelial cells, and fibroblasts Of these stromal cells, it is increasingly clear that active fibroblasts The aim was to explore the relationship between myxoid stroma (one of the forms of DR) and postoperative relapse in patients with stage II colon cancer
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