Abstract
Objectives The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern. Methods 148 MLs were analyzed. The sites of metastases were investigated. Results Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases. Conclusion Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.
Highlights
Liposarcoma is one of the most common sarcomas found in adults [1, 2] and it can be defined as a mesenchymal malignancy characterized by adipocyte differentiation
5 (3%) liposarcomas were localized at the muscles of the shoulder, 3 at the arm, 5 at the elbow and distal to the elbow, 10 in pelvic muscles, 76 in the thigh, and 43 in the knee and distal to the knee
The preoperative radiotherapy was performed in 41 myxoid liposarcoma (MLs) (14 cases with size > 10 cm, 18 cases between 5 and 10 cm, and 9 cases with dimensions < 5); the postoperative radiotherapy was performed in 63 patients (14 < 5 cm, 32 between 5 and 10 cm, and 17 > 10 cm) of which 17 patients had marginal or compromised margins at histological examination and in 30 patients with high grade MLs (Table 2)
Summary
Liposarcoma is one of the most common sarcomas found in adults [1, 2] and it can be defined as a mesenchymal malignancy characterized by adipocyte differentiation. Myxoid liposarcoma is the second most common subtype (MLs). It accounts for 15–20% of liposarcomas and represents about 5% of all soft tissue sarcomas in adults. A variant t(12;22)(q13;q12) is present in which DDIT3 ( known as CHOP) fuses instead with EWSR1, a gene that is highly related to FUS. They have a peak incidence in the fourth and fifth decade of life, in particular on the lower extremities and buttock [2, 6, 7]
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