Abstract
Leiomyoma of vulva is rare, and usually misdiagnosed clinically as Bartholin cyst. It usually presents spindle-shaped tumor cells, but some rare cases consisted mainly of atypical epithelioid tumor cells. We report here a case of 30-year-old woman consulting with a vulvar mass of 7 cm in the Bartholin glands area. The lesion was surgically excised with its capsule completely. Pathological examination and immunochemistry showed characteristic of epithelioid leiomyoma with myxoid stroma with both estrogen receptor (ER) and progesterone receptor (PR) staining negative, which was really rare as only 2 cases of vulvar leiomyoma with both ER and PR were reported before.
Highlights
Smooth muscle tumors of the vulva are rare and are usually misdiagnosed clinically as Bartholin cysts
We report a case of vulvar epithelioid leiomyoma which was misdiagnosed with Bartholin cysts and confused us for the untypical microscopical findings and immunohistochemistry results
The gross specimen consisted of a soft mass measuring 7 cm in diameter
Summary
Smooth muscle tumors of the vulva are rare and are usually misdiagnosed clinically as Bartholin cysts. These tumors are considered to originate from smooth muscle within erectile tissue, blood vessel walls, the round ligament, the dartos muscle, or the arrector pili muscle [1] and from the stem cells localized in Bartholin’s gland [2]. Immunohistochemistry plays an important role in differential diagnoses. These tumors usually present positive for anti-smooth muscle antibody (SMA), desmin, and vimentin. We report a case of vulvar epithelioid leiomyoma which was misdiagnosed with Bartholin cysts and confused us for the untypical microscopical findings and immunohistochemistry results
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