Abstract
5-year survival of 100%. 3,5 This relapse rate is in the range of that observed after radiation, recurrences are mostly retroperitoneal, and effective salvage is almost invariably obtained with four courses of cisplatin-based chemotherapy. Furthermore, an adequate follow-up (median, 72 months) in this pooled analysis precludes the chance of significant late adverse effects or late relapses, while showing a significant reduction in the probability of second germ-cell tumors. In this context, it is conceptually difficult to continue recommending systematic (indiscriminate) prophylactic radiation because more than 80% of these patients are cured with orchiectomy alone and the late hazards of radiotherapy (mainly second malignancies)arewellknown.Moreover,althoughpredictivefactorsfor
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