Abstract
Mysteries of type I IFN response: benefits versus detriments.
Highlights
The original research performed by Babb et al investigates the potential adjuvant activity of gamma-irradiated influenza [1]
They demonstrate that co-vaccination with gamma-irradiatedinfluenza virus and poorly immunogenic inactivated Semliki forest virus (SFV) results in enhanced SFV-specific antibody responses without compromising humoral immunity against influenza infections
These authors speculate that gamma-irradiated influenza virus may be exploited as an adjuvant to improve the efficacy of poorly immunogenic vaccines owing to its ability to stimulate IFN-I production
Summary
The original research performed by Babb et al investigates the potential adjuvant activity of gamma-irradiated influenza [1]. It is likely that the adjuvant activity of gamma-irradiated influenza virus is attributable to its potency of IFN-I induction. These authors speculate that gamma-irradiated influenza virus may be exploited as an adjuvant to improve the efficacy of poorly immunogenic vaccines owing to its ability to stimulate IFN-I production.
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