Myostatin Level in CRF Patients with and without HBV and Its Correlation with Sarcopenia

Abstract

Abstract Introduction Myostatin (MSTN), a member of TGF-β superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic kidney disease (CKD), which may play a role in the pathogenesis of sarcopenia or in the protein energy wasting (PEW). Aim and objectives To assess myostatin level in CRF patients with HBV and its correlation with sarcopenia. Subjects and Methods This study is a cross - sectional study, was carried out at at outpatients' clinics and internal medicine and nephrology department Ain Shams university hospital and Sharq Elmadinah Hospital, Alexandria, on 70 patients on regular hemodialysis divided into 3 groups: (Group A); included 20 patients with HBV infection, (Group B); included 20 patients without HBV infection, (Group C); included 10 normal persons without CRF or HBV, during period from February 2021 till August 2021. Result Myostatin level showed a significant negative correlation with BMI and SMI. Conclusion The serum myostatin level was significantly higher in hemodialysis patients than controls, particularly in post-HCV cirrhotic than non-cirrhotic ones. Serum myostatin level was significantly related to sarcopenia pathogenesis as a predictor marker.