Abstract
Myositis ossificans progressiva (MOP) is an autosomal dominant disorder. There is a progressive ectopic ossification and skeletal malformation, mainly in the connective tissue of muscle. The diagnosis is based on the clinical findings and radiological demonstration of the skeletal malformations. A 38-year-old female patient was admitted to our department with progressive increase of the thigh. Results of laboratory studies were normal. The radiography of the right thigh showed multiple intramuscular calcifications. Myositis ossificans progressiva should be diagnosed as early as possible and non-invasively, based upon history, clinical and radiological findings. Early and correct diagnosis is fundamental for indication of proper management of the disease.
Highlights
Myositis ossificans progressiva (MOP) is an autosomal dominant disorder
And correct diagnosis is fundamental for indication of proper management of the disease .We report the case of a 38-year-old woman with clinical and radiological features of MOP
Myositis ossificans progressiva is a rare hereditary mesodermal disorder, It is a mutation in chromosome 2 in the bone morphogenetic protein type, receptor ACVRI, with an incidence of less than 1 in 10,000,000 populations affecting all ethnic backgrounds with both sexes [1]
Summary
Myositis ossificans progressiva (MOP) is an autosomal dominant disorder. This disease is very rare with an incidence of less than 1 in 10,000,000 populations. There is a progressive ectopic ossification and skeletal malformation, mainly in the connective tissue of muscle. And correct diagnosis is fundamental for indication of proper management of the disease .We report the case of a 38-year-old woman with clinical and radiological features of MOP. A 38 -year-old female patient consulted at our department .She has no family or individual medical history. She has presented 3 years earlier, a progressive increase in thigh volume with functional disability. Written informed consent was obtained from the patient's legal guardian for publication of the case
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