Abstract
Myosin I is a single-headed myosin molecule that plays a role in regulating membrane dynamics and structure in eukaryotic cells. Its best-characterized function is to provide tension to sensitize mechanosensitive ion channels responsible for hearing. Myosin I is thought to function by sensing tension and changing its motile properties in response to changes in loads. Laakso et al . used single-molecule measurements to characterize the motor activity of myosin I. Small resisting loads (<2 pN) resulted in a 75 times lower rate of myosin I detachment from actin, dramatically changing its motor properties. This acute sensitivity supports models in which myosin I functions as a molecular force sensor. J. M. Laakso, J. H. Lewis, H. Shuman, E. M. Ostap, Myosin I can act as a molecular force sensor. Science 321 , 133-136 (2008). [Abstract] [Full Text]
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