Abstract
Striated muscle contraction is modulated by structural changes in both myosin thick filaments and actin thin filaments. Yet, the signaling pathway between myofilaments is unknown. The thick filament mechanism involves movement of myosin heads (likely force/strain-dependent) from a folded, horizontal position on thick filament backbone (OFF) to a more perpendicular orientation (ON), closer to thin filament. Upon binding of calcium by troponin, the thin filament mechanism involves movement of tropomyosin from periphery of thin filament to the actin groove, enabling myosin crossbridge formation and force generation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
