Abstract
Striated muscle contraction is modulated by structural changes in both myosin thick filaments and actin thin filaments. Yet, the signaling pathway between myofilaments is unknown. The thick filament mechanism involves movement of myosin heads (likely force/strain-dependent) from a folded, horizontal position on thick filament backbone (OFF) to a more perpendicular orientation (ON), closer to thin filament. Upon binding of calcium by troponin, the thin filament mechanism involves movement of tropomyosin from periphery of thin filament to the actin groove, enabling myosin crossbridge formation and force generation.
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