Abstract
Podosomes represent a special class of integrin-mediated cell-matrix adhesions formed by migrating and matrix degrading cells. Here, we demonstrated that in macrophage-like THP1 cells and in fibroblasts stimulated to produce podosomes, down-regulation of ARF1 by siRNA, and by pharmacological inhibitors led to striking podosome elimination. Treatments that induced podosome formation increased the level of GTP-bound ARF1. Furthermore, siRNA knockdown of the ARF1-GEF ARNO also resulted in dramatic podosome inhibition.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.