Abstract
There are limited data on age-related changes in body composition or skeletal muscle in the horse. Therefore, the purpose of this study was to investigate any differences in muscle myosin heavy chain (MHC) and body composition associated with aging. Twenty-three young (4–8 years) and eight old (20+ years) unfit Standardbred mares were evaluated. Rump fat thickness was measured using B-mode ultrasound and per cent body fat (% fat) was calculated. Needle muscle biopsies were obtained from right gluteus medius muscle. MHC composition was determined via sodium dodecyl sulphate–polyacrylamide gel electrophoresis. Three MHC isoforms were subsequently identified as type I, type IIA, and type IIX and quantified using a scanning and densometric system. There were no significant differences ( p>0.05) between old and young mares in fat (%) (19.0±6.4 vs 20.5±5.4), fat mass (kg) (102.3±39.9 vs 106.9±37.1), or body weight (kg) (529.4±34.9 vs 512.7±57.7). However, the old mares had significantly ( p<0.05) greater lean body mass than the young mares (427.1±24.5 vs 405.7±37.9). Aged mares had significantly ( p<0.05) less type I (7.8±2.9% vs 12.1±4.4%) and IIA (27.8±7.1% vs 36.1±9.5%) fibres than the young group but more type IIX (64.6±4.7% vs 51.8±11.1%). The MHC data are consistent with the age-related changes seen in other species.
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