Abstract
Myopia is amongst the most common refractive errors in the world. Both environmental and genetic factors are attributed to its causation, however all factors contributing to the development of myopia is yet to be found. Recent studies show presence of sex hormone receptor in the eyes. This has been shown to have a role in the development of various ocular pathologies. The second to fourth finger length ratio (2D:4D) has been hypothesised to be determined by exposure to sex steroids prenatally and thus considered a crude measure for prenatal androgen exposure. Hence this study was initiated to assess the association between myopia and 2D:4D ratio (a proxy marker to prenatal sex steroid exposure) among 100 medical college students of either sex and explore the possibility of role of prenatal sex steroids in causation of myopia. This study showed significant negative associations between myopia and digit ratio favouring a probable causal role of sex steroids on eye growth and development of myopia.
Highlights
Myopia is the most common refractive errors in the world varying by country and ethnicity, reaching as high as 70–90% in certain Asian populations [1,2]
The present study aimed to explore the relationship between myopia and 2D:4D ratio in Medical college students
The present study aimed to explore the relationship between myopia and 2D:4D ratio among medical college students
Summary
Myopia is the most common refractive errors in the world varying by country and ethnicity, reaching as high as 70–90% in certain Asian populations [1,2]. In spite of numerous published works, search is on to identify various lesser known factors apart from environmental and genetic factors in the aetiology of myopia and excessive eye growth [3]. It usually occurs from a failure of the coordination of postnatal growth of whole eyeball with refractive components of the eye. Myopia in particular is linked with enhanced mathematical ability, tendency of high IQ and left handedness [7]. The exact reason for this asynchrony and an explanation for myopia, laterality and IQ are lacking and it has been hypothesized that there may be a link between eyeball axial length and cerebral development, or that all may be influenced by the same genes and factors [8]
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