Myopalladin is upregulated in dilated cardiomyopathies patients and myopalladin knockout mice develop cardiac dilation and dysfunction following pressure overload

Abstract

Background: Myopalladin (MYPN) is a 145 kDa striated muscle-specific sarcomeric protein belonging to the palladin (PALLD)/MYPN/myotilin family of actin-associated immunoglobulin-containing proteins in the Z-line. MYPN gene mutations are causative for dilated (DCM), hypertrophic and restrictive cardiomyopathy.